Beilstein J. Org. Chem.2017,13, 845–854, doi:10.3762/bjoc.13.85
terpene producing Escherichia coli, this review shall give an insight in recent progresses regarding manipulation of mostly diterpene synthases.
Keywords: enzyme engineering; heterologous production in E. coli; metabolic pathway optimization; modularbiosynthesis; plant diterpenes; Introduction
iceberg. Potentially, modularbiosynthesis that has resources to fast expanding databases will widen the amenable targets for large scale production to unforeseen extend. As a prerequisite, strain optimization of heterologous hosts has to be developing with equal progress although continuous reporting
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Graphical Abstract
Scheme 1:
Isoprenoid biosynthetic pathways and examples for their engineering in heterologous production syst...